The author studied the changes of rabbit´s renal and heapatic functions following oral administration of paraquat solution devided 20㎎, 40㎎, 80㎎, 150㎎ and 300㎎ respectively. Thirty adult male rabbits were divided into Group Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ and control groups. Each diluted paraquat solutions were administrated by Foley Catheter No. 18 into each experimental group. Control group was administrated with distilled saline. Five ml of blood samples were drawn from heart puncture at 3, 12, 24, 48 and 72 hours after intoxication, respectively. Serum creatinine, BUN, uric acid total protein, albumin, total cholesterol, total bilirubin, alkaline phosphatase, ALT and AST were analyzed.
The following results were obtained.
1. Serum creatinine level was markedly elevated at 13 hours after intoxication, and then slowly declined in experimntal groups.
2. BUN level was markedly elevated in all groups after intoxicatin, thereafter the elevated level was maintained.
3. Serum total cholesterol and alkaline phosphatase levels were markedly elevated at 3 hours after intoxication in all experimental groups, but both of them were declined after 48 hours in Group I only.
4. Serum ALT level was markedly elevated at 24 hours after intoxication in Group Ⅱ and Ⅲ, whereas the serum levels of Group Ⅳ and Ⅴ were markedly elevated at 3 hours after intoxication.
5. Serum AST level was markedly elevated at 24 hours after intoxication in Group Ⅱ whereas the serum levels of Group Ⅲ, Ⅳ and Ⅴ were markedly elevated at 3 hours after intoxication.
6. No changes of serum uric acid, total protein, albumin and total bilirubin levels were founded in all experimental groups.
In summary, BUN, serum total cholesterol and alkaline phosphatase in early stage of actue paraquat intoxication are recommanded as serum creatinine, ALT and AST after 24 hours are required for management of intoxication.
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